Big Mac Casserole with Ground Beef and Cheese Sauce

Prep: 20 minCook: 35 min6 servingsmediumAmerican
Big Mac Casserole with Ground Beef and Cheese Sauce

A hearty baked casserole that captures all the flavors of a Big Mac burger in comfort food form. Ground beef seasoned with Worcestershire and vinegar gets topped with a tangy sauce made from mayo, sugar-free ketchup, and mustard, then blanketed with melted cheddar and mozzarella. Fresh lettuce and pickles added after baking provide the signature crunch and bright flavor that makes this dish instantly recognizable. Perfect for family dinners when you want familiar flavors in a new format.

Ingredients

6 servings
  • 1 ½ pounds ground beef
    ground turkey1:1healthier

    slightly leaner texture

    Full guide →
  • ½ cup onion, diced
  • 2 cloves garlic, minced
  • 1 teaspoon sea salt
  • ½ teaspoon ground black pepper
  • 2 tablespoons Worcestershire sauce
  • 1 tablespoon apple cider vinegar
  • 1 cup cheddar cheese, shredded
  • 1 cup mozzarella cheese, shredded
  • 3 cups iceberg lettuce, shredded
    romaine lettuce1:1texture

    more nutritious

    Full guide →
  • ½ cup pickles, diced
  • ½ cup unsweetened dill pickle relish
  • ½ cup mayonnaise
  • 2 tablespoons sugar-free ketchup
    regular ketchup1:1standard

    adds carbs

  • 1 tablespoon mustard
  • 1 teaspoon white vinegar
  • 1 teaspoon paprika
  • ½ teaspoon onion powder
  • ¼ teaspoon garlic powder

Instructions

  1. 1

    Preheat oven to 350°F

  2. 2

    Brown ground beef with onion and garlic in large skillet over medium-high heat, season with salt and pepper until beef is no longer pink and onions are translucent, drain excess fat

  3. 3

    Stir Worcestershire sauce and apple cider vinegar into beef mixture, cook for additional 2 minutes

  4. 4

    Transfer beef mixture to greased 9x13 inch baking dish

  5. 5

    Whisk together mayonnaise, sugar-free ketchup, mustard, white vinegar, paprika, onion powder, and garlic powder in small bowl

  6. 6

    Spread sauce evenly over beef mixture in baking dish

  7. 7

    Sprinkle cheddar and mozzarella cheese over sauce layer

  8. 8

    Bake for 20-25 minutes until cheese is melted and bubbly

  9. 9

    Shred lettuce and dice pickles while casserole bakes

  10. 10

    Let casserole cool for 5 minutes after baking

  11. 11

    Top with shredded lettuce and diced pickles

  12. 12

    Serve immediately, garnished with dill pickle relish

Tips

Tip 1

Drain the ground beef thoroughly after browning to prevent a greasy casserole that won't hold together well when serving.

Tip 2

Let the casserole rest for 5 minutes before adding lettuce and pickles so the heat doesn't wilt the fresh toppings.

Tip 3

Use a mix of cheddar and mozzarella for the best melting texture and flavor balance in the cheese layer.

Good to Know

Storage

Refrigerate covered for up to 3 days. Reheat in oven at 350°F until heated through.

Make Ahead

Can assemble through step 7 and refrigerate up to 24 hours before baking. Add 5-10 minutes to baking time if cold.

Serve With

Serve hot immediately after adding fresh toppings for best texture contrast.

See pairing guide →

Common Mistakes

Watch

Don't add lettuce and pickles while hot to avoid wilting and sogginess.

Watch

Drain beef thoroughly to prevent excess grease pooling in the casserole.

Substitutions

iceberg lettuce
romaine lettuce1:1texture

more nutritious

Full guide →
ground beef
ground turkey1:1healthier

slightly leaner texture

Full guide →
sugar-free ketchup
regular ketchup1:1standard

adds carbs

Find more substitutions →

FAQ

Can I make this ahead?

Yes, assemble through the cheese layer and refrigerate up to 24 hours. Add fresh toppings after baking and increase baking time by 5-10 minutes.

What if I don't have sugar-free ketchup?

Regular ketchup works but adds carbs and sugar. Use 1-2 tablespoons less to reduce sweetness if desired.

How long does this keep?

Refrigerate covered for up to 3 days. The lettuce and pickles are best added fresh when serving leftovers.