Gluten-Free Bubble Up Enchilada Casserole

Prep: 15 minCook: 30 min6 servingsmediumMexican
Bubble Up Enchilada Casserole with Ground Beef and Biscuits

A hearty one-dish dinner that combines seasoned ground beef with enchilada sauce and diced tomatoes, topped with fluffy biscuit pieces and melted cheddar cheese. The biscuits 'bubble up' through the savory beef mixture as it bakes, creating a comforting casserole that's perfect for busy weeknight dinners. This crowd-pleasing dish delivers bold Southwest flavors with minimal prep work, making it ideal for feeding hungry families or casual gatherings.

Ingredients

6 servings
  • 1 lb ground beef
    ground turkey1:1protein

    slightly leaner option

    Full guide →
  • 1 can enchilada sauce, 10 oz
  • 1 can diced tomatoes with green chilies, 10 oz
  • 1 cup shredded cheddar cheese
    Mexican cheese blend1:1flavor

    adds authentic Mexican flavors

    Full guide →
  • 1 can Pillsbury Grands biscuits, 16 oz

Instructions

  1. 1

    Preheat oven to 350°F

  2. 2

    Cook ground beef in skillet until browned and drain fat

  3. 3

    Combine cooked beef, enchilada sauce, and diced tomatoes with green chilies in mixing bowl

  4. 4

    Cut biscuits into quarters and stir into beef mixture

  5. 5

    Pour mixture into baking dish and top with shredded cheddar cheese

  6. 6

    Bake for 25-30 minutes until biscuits are cooked through and cheese is bubbly

Tips

Tip 1

Drain the ground beef thoroughly to prevent the casserole from becoming greasy during baking.

Tip 2

Cut biscuits into uniform quarters so they cook evenly throughout the casserole.

Tip 3

Let the casserole rest for 5 minutes after baking to allow the cheese to set slightly before serving.

Good to Know

Storage

Refrigerate leftovers for up to 3 days in covered container.

Make Ahead

Assemble casserole up to 4 hours ahead, cover and refrigerate, then bake as directed adding 5-10 minutes.

Serve With

Serve hot directly from baking dish with sour cream, salsa, or chopped cilantro as desired.

See pairing guide →

Common Mistakes

Watch

Don't skip draining the beef fat to avoid a greasy casserole

Watch

Avoid overbaking or the biscuits will become dry and tough

Substitutions

ground beef
ground turkey1:1protein

slightly leaner option

Full guide →
cheddar cheese
Mexican cheese blend1:1flavor

adds authentic Mexican flavors

Full guide →
Pillsbury biscuits
refrigerated cornbread1:1texture

adds corn flavor and firmer texture

Find more substitutions →

FAQ

Can I use fresh biscuits instead of canned?

Yes, cut homemade biscuit dough into quarters and proceed with recipe. Fresh biscuits may need slightly longer baking time.

What if I don't have enchilada sauce?

Substitute with equal amount of salsa mixed with 2 tablespoons tomato paste for similar flavor and consistency.

How long will leftovers keep?

Store covered in refrigerator for up to 3 days. Reheat individual portions in microwave or whole casserole in 350°F oven.