Easy 5-Ingredient Chicken Alfredo Bubble-Up Bake

A hearty casserole that combines tender rotisserie chicken, fresh spinach, and creamy Alfredo sauce with fluffy buttermilk biscuit pieces. The biscuits create delightful bubbles throughout the dish as they bake, earning its 'bubble-up' name. Perfect for busy weeknight dinners when you need comfort food fast, this one-dish meal requires minimal prep and delivers maximum satisfaction. The melted mozzarella on top creates a golden, bubbly crust that contrasts beautifully with the creamy interior.
Ingredients
- 2 cups deli rotisserie chicken, coarsely chopped
- 2 cups fresh baby spinach, chopped
- 1 jar (15 oz) Alfredo pasta sauce
- 2 cups mozzarella cheese, shredded (8 oz)
- 1 can (16.3 oz) Pillsbury Grands Southern Homestyle Buttermilk Biscuits, 8 Count
Instructions
- 1
Heat oven and spray baking dish with cooking spray
- 2
Mix chicken, spinach, Alfredo sauce and half the cheese in large bowl
- 3
Cut each biscuit into 6 pieces and add to bowl, stir gently
- 4
Spoon mixture into baking dish and top with remaining cheese
- 5
Bake until deep golden brown and biscuits are cooked through
Tips
Use a glass baking dish as specified for even heating and to monitor browning through the bottom.
Cut biscuits while cold from the refrigerator for cleaner, easier cutting into pieces.
Let rest 5 minutes before serving to allow the Alfredo sauce to set slightly.
Good to Know
Refrigerate leftovers up to 3 days. Cover tightly to prevent drying out.
Can assemble up to 4 hours ahead. Cover and refrigerate, then bake as directed, adding 5-10 minutes if needed.
Serve hot directly from the baking dish with a side salad or steamed vegetables.
Common Mistakes
Don't overbake or biscuits will become tough and dry.
Cut biscuits evenly to ensure uniform cooking throughout the casserole.
Substitutions
FAQ
Can I use fresh biscuits instead of refrigerated?
Yes, but homemade biscuits may have different baking times. Monitor closely and adjust as needed.
How long will leftovers keep?
Properly stored in the refrigerator, leftovers will keep for 3-4 days. Reheat in oven or microwave.
Can I freeze this casserole?
Yes, assemble without baking, wrap tightly, and freeze up to 3 months. Thaw overnight before baking.