Easy 5-Ingredient Chicken Alfredo Bubble-Up Bake

Prep: 10 minCook: 40 min8 servingsmediumAmerican
Easy 5-Ingredient Chicken Alfredo Bubble-Up Bake

A hearty casserole that combines tender rotisserie chicken, fresh spinach, and creamy Alfredo sauce with fluffy buttermilk biscuit pieces. The biscuits create delightful bubbles throughout the dish as they bake, earning its 'bubble-up' name. Perfect for busy weeknight dinners when you need comfort food fast, this one-dish meal requires minimal prep and delivers maximum satisfaction. The melted mozzarella on top creates a golden, bubbly crust that contrasts beautifully with the creamy interior.

Ingredients

8 servings
  • 2 cups deli rotisserie chicken, coarsely chopped
    cooked chicken breast1:1

    Use any leftover cooked chicken

    Full guide →
  • 2 cups fresh baby spinach, chopped
    frozen spinach1:1

    Thaw and drain well before using

    Full guide →
  • 1 jar (15 oz) Alfredo pasta sauce
  • 2 cups mozzarella cheese, shredded (8 oz)
    Italian cheese blend1:1

    Any melting cheese works well

    Full guide →
  • 1 can (16.3 oz) Pillsbury Grands Southern Homestyle Buttermilk Biscuits, 8 Count

Instructions

  1. 1

    Heat oven and spray baking dish with cooking spray

  2. 2

    Mix chicken, spinach, Alfredo sauce and half the cheese in large bowl

  3. 3

    Cut each biscuit into 6 pieces and add to bowl, stir gently

  4. 4

    Spoon mixture into baking dish and top with remaining cheese

  5. 5

    Bake until deep golden brown and biscuits are cooked through

Tips

Tip 1

Use a glass baking dish as specified for even heating and to monitor browning through the bottom.

Tip 2

Cut biscuits while cold from the refrigerator for cleaner, easier cutting into pieces.

Tip 3

Let rest 5 minutes before serving to allow the Alfredo sauce to set slightly.

Good to Know

Storage

Refrigerate leftovers up to 3 days. Cover tightly to prevent drying out.

Make Ahead

Can assemble up to 4 hours ahead. Cover and refrigerate, then bake as directed, adding 5-10 minutes if needed.

Serve With

Serve hot directly from the baking dish with a side salad or steamed vegetables.

See pairing guide →

Common Mistakes

Watch

Don't overbake or biscuits will become tough and dry.

Watch

Cut biscuits evenly to ensure uniform cooking throughout the casserole.

Substitutions

rotisserie chicken
cooked chicken breast1:1

Use any leftover cooked chicken

Full guide →
fresh spinach
frozen spinach1:1

Thaw and drain well before using

Full guide →
mozzarella
Italian cheese blend1:1

Any melting cheese works well

Full guide →
Find more substitutions →

FAQ

Can I use fresh biscuits instead of refrigerated?

Yes, but homemade biscuits may have different baking times. Monitor closely and adjust as needed.

How long will leftovers keep?

Properly stored in the refrigerator, leftovers will keep for 3-4 days. Reheat in oven or microwave.

Can I freeze this casserole?

Yes, assemble without baking, wrap tightly, and freeze up to 3 months. Thaw overnight before baking.