Gluten-Free Ground Beef and Biscuit Casserole

Prep: 15 minCook: 35 min6 servingsmedium
Ground Beef and Biscuit Casserole with Cream of Mushroom

A hearty one-dish comfort meal featuring seasoned ground beef in a creamy mushroom and cheese sauce, topped with golden biscuits. The combination of cream cheese and condensed soup creates a rich, satisfying base that pairs perfectly with fluffy baked biscuits. This family-friendly casserole works well for busy weeknight dinners or casual gatherings when you need something filling and comforting. The dish stands out for its simple preparation method and the way the biscuits bake directly on top of the beef mixture, creating a complete meal in one pan.

Ingredients

6 servings
  • 1 ½ lbs ground beef
    ground turkey1:1healthier

    Use same cooking method

    Full guide →
  • 1 cup onion, chopped
  • 1 clove garlic, minced
  • 10 ¾ ounce cream of mushroom soup, canned
    cream of celery soup1:1flavor variation

    Works equally well

    Full guide →
  • 8 ounce cream cheese, softened
  • ¼ cup milk
  • ¼ cup ketchup
  • 1 teaspoon salt
  • 10 ounce refrigerated biscuits, to cover
    homemade biscuit dough1:1from scratch

    Roll and cut to fit casserole

Instructions

  1. 1

    Brown ground beef, onion, and garlic in a large skillet, stirring until meat crumbles

  2. 2

    Drain the cooked beef mixture and set aside

  3. 3

    Combine cream of mushroom soup, cream cheese, milk, ketchup, and salt in a large bowl

  4. 4

    Stir the soup mixture well until combined

  5. 5

    Add the reserved ground beef mixture to the soup mixture and stir well

  6. 6

    Place the mixture in a lightly greased 2 quart casserole

  7. 7

    Bake uncovered for 10 minutes

  8. 8

    Place biscuits on top of the ground beef mixture

  9. 9

    Bake an additional 15 to 20 minutes or until biscuits are done

Tips

Tip 1

Let cream cheese soften at room temperature for easier mixing with the soup mixture

Tip 2

Drain the ground beef well to prevent the casserole from becoming watery

Tip 3

Check biscuit doneness by looking for golden brown tops and cooked-through centers

Good to Know

Storage

Refrigerate leftovers up to 3 days in covered container

Make Ahead

Assemble casserole without biscuits up to 1 day ahead, add biscuits before baking

Serve With

Serve hot directly from casserole dish with vegetables or salad

See pairing guide →

Common Mistakes

Watch

Drain ground beef thoroughly to avoid watery casserole

Watch

Let cream cheese soften completely to avoid lumps in sauce

Substitutions

cream of mushroom soup
cream of celery soup1:1flavor variation

Works equally well

Full guide →
ground beef
ground turkey1:1healthier

Use same cooking method

Full guide →
refrigerated biscuits
homemade biscuit dough1:1from scratch

Roll and cut to fit casserole

Find more substitutions →

FAQ

Can I use fresh biscuits instead of refrigerated?

Yes, fresh homemade biscuits work perfectly. Roll the dough and cut into pieces that will cover the casserole surface evenly.

What if I don't have cream of mushroom soup?

Cream of celery or cream of chicken soup work as substitutes. The flavor will be slightly different but equally delicious.

How long will leftovers keep in the refrigerator?

Store covered leftovers in the refrigerator for up to 3 days. Reheat individual portions in the microwave or oven until heated through.