Gluten-Free Ground Beef and Biscuit Casserole

A hearty one-dish comfort meal featuring seasoned ground beef in a creamy mushroom and cheese sauce, topped with golden biscuits. The combination of cream cheese and condensed soup creates a rich, satisfying base that pairs perfectly with fluffy baked biscuits. This family-friendly casserole works well for busy weeknight dinners or casual gatherings when you need something filling and comforting. The dish stands out for its simple preparation method and the way the biscuits bake directly on top of the beef mixture, creating a complete meal in one pan.
Ingredients
Instructions
- 1
Brown ground beef, onion, and garlic in a large skillet, stirring until meat crumbles
- 2
Drain the cooked beef mixture and set aside
- 3
Combine cream of mushroom soup, cream cheese, milk, ketchup, and salt in a large bowl
- 4
Stir the soup mixture well until combined
- 5
Add the reserved ground beef mixture to the soup mixture and stir well
- 6
Place the mixture in a lightly greased 2 quart casserole
- 7
Bake uncovered for 10 minutes
- 8
Place biscuits on top of the ground beef mixture
- 9
Bake an additional 15 to 20 minutes or until biscuits are done
Tips
Let cream cheese soften at room temperature for easier mixing with the soup mixture
Drain the ground beef well to prevent the casserole from becoming watery
Check biscuit doneness by looking for golden brown tops and cooked-through centers
Good to Know
Refrigerate leftovers up to 3 days in covered container
Assemble casserole without biscuits up to 1 day ahead, add biscuits before baking
Serve hot directly from casserole dish with vegetables or salad
Common Mistakes
Drain ground beef thoroughly to avoid watery casserole
Let cream cheese soften completely to avoid lumps in sauce
Substitutions
Roll and cut to fit casserole
FAQ
Can I use fresh biscuits instead of refrigerated?
Yes, fresh homemade biscuits work perfectly. Roll the dough and cut into pieces that will cover the casserole surface evenly.
What if I don't have cream of mushroom soup?
Cream of celery or cream of chicken soup work as substitutes. The flavor will be slightly different but equally delicious.
How long will leftovers keep in the refrigerator?
Store covered leftovers in the refrigerator for up to 3 days. Reheat individual portions in the microwave or oven until heated through.