Baked Mexican Penne Mac and Cheese with Yogurt Sauce

Prep: 25 min6 servingsmediumMexican
Baked Mexican Penne Mac and Cheese with Yogurt Sauce

This creamy baked pasta combines tangy Greek yogurt with melted American and Mexican cheeses for a lighter twist on classic mac and cheese. The addition of ground mustard and garlic creates depth while the bread crumb topping adds satisfying crunch. Perfect for family dinners or potluck gatherings, this comforting casserole delivers all the cheesy goodness you crave with reduced fat content. The yogurt creates an unexpectedly smooth sauce that pairs beautifully with the spiced cheese blend.

Ingredients

6 servings
  • 2 ⅝ cups uncooked penne pasta
  • 2 tablespoons butter or margarine
    vegan butter1:1vegandairy-free

    Use plant-based spread

    Full guide →
  • ¼ cup onion, chopped
  • 1 teaspoon ground mustard
  • ¼ teaspoon salt
  • teaspoon pepper
  • 1 clove garlic, finely chopped
  • 2 tablespoons Gold Medal all-purpose flour
    almond flour1:1gluten-freegluten-free

    May affect texture slightly

  • 2 cups Yoplait Fat Free plain yogurt, from 2-lb container
    sour cream1:1traditional

    Creates richer flavor

    Full guide →
  • 4 oz light process American cheese product loaf, cut into 1/2-inch cubes
  • 1 cup shredded reduced-fat Mexican 4-cheese blend, 4 oz
  • ¼ cup Progresso plain bread crumbs
    panko crumbs1:1crispyadds gluten

    Extra crunchy topping

    Full guide →

Instructions

  1. 1

    Heat oven to 375°F

  2. 2

    Cook and drain pasta as directed on package and set aside

  3. 3

    Melt butter in 3-quart saucepan over medium heat

  4. 4

    Add onion, mustard, salt, pepper and garlic and cook 5 to 7 minutes, stirring occasionally, until onion is tender

  5. 5

    Stir in flour

  6. 6

    Cook over medium-low heat, stirring constantly, until mixture is bubbly

  7. 7

    Remove from heat

  8. 8

    Stir in yogurt, stirring constantly

  9. 9

    Gently stir in cheeses and stir in pasta

  10. 10

    Pour into ungreased 2-quart casserole

  11. 11

    Sprinkle with bread crumbs

  12. 12

    Bake uncovered about 25 minutes or until bubbly

Tips

Tip 1

Use room temperature yogurt to prevent curdling when adding to the hot flour mixture

Tip 2

Let the casserole rest 5 minutes after baking for easier serving and better texture

Tip 3

Stir gently when combining cheeses to avoid breaking the delicate yogurt sauce

Good to Know

Storage

Refrigerate covered up to 3 days. Reheat in 350°F oven until heated through.

Make Ahead

Can assemble casserole up to 1 day ahead. Cover and refrigerate, then bake as directed adding 10-15 minutes.

Serve With

Serve hot directly from the casserole dish with a green salad or steamed vegetables.

See pairing guide →

Common Mistakes

Watch

Add yogurt gradually while stirring to avoid curdling

Watch

Don't overbake or the yogurt sauce may separate

Watch

Use low heat when making the roux to prevent burning

Substitutions

Dairy-Free Swaps

butter
vegan butter1:1vegandairy-free

Use plant-based spread

Full guide →

Gluten-Free Swaps

all-purpose flour
almond flour1:1gluten-freegluten-free

May affect texture slightly

Full guide →

General Alternatives

plain yogurt
sour cream1:1traditional

Creates richer flavor

Full guide →
Mexican cheese blend
cheddar cheese1:1mild

Less spicy flavor

Full guide →
bread crumbs
panko crumbs1:1crispyadds gluten

Extra crunchy topping

Full guide →
Find more substitutions →

FAQ

Can I use regular pasta instead of penne?

Yes, any short pasta like rotini, shells, or elbows works well. Cook according to package directions and use the same amount.

What if I don't have Mexican cheese blend?

Substitute with a mix of cheddar, Monterey Jack, and pepper jack cheese, or use all cheddar for a milder flavor.

How long will leftovers keep?

Store covered in the refrigerator for up to 3 days. Reheat portions in the microwave or warm the whole dish in a 350°F oven.